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Vitamin B6 is also required for sphingolipid synthesisa class of fats located in nerve cell membranes and the myelin sheath, the insulating layer protecting axons and allowing for rapid and efficient electrical impulse transmission

This mechanistic breadth has made BPC-157 a uniquely productive research compound for studying cytoprotection and tissue repair across multiple organ systems simultaneously

The study was designed to show that overall survival with pemetrexed was non-inferior to docetaxel, as the major efficacy outcome measure, and that overall survival was superior for patients randomized to pemetrexed compared to docetaxel, as a secondary outcome measure